Prof. Yigong Shi's laboratory combines structural biology, biochemical and biophysical approaches to elucidate the molecular and chemical basis of fundamental cellular events. We are particularly interested in the regulation of apoptosis, the assembly and dynamics of macromolecular machineries exemplified by spliceosome and proteasome, and the mechanism of regulated intramembrane proteolysis with a focus on the structure and function of γ-secretase, a 4-component membrane complex that is associated with the development of Alzheimer's disease.

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